Regulation of chitin synthesis in pathogenic fungi: An update
10.3724/SP.J.1008.2014.00549
- Author:
Nan-Xin ZHENG
1
Author Information
1. College of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Chitin;
Chitin synthase;
Drug target;
Fungi;
Regulation mechanism
- From:
Academic Journal of Second Military Medical University
2014;35(5):549-554
- CountryChina
- Language:Chinese
-
Abstract:
hitin, an essential component of the cell wall, exists widely in pathogenic fungi. Chitin synthase (CHS) is a key enzyme for biosynthesis of chitin, and its activity is strictly regulated; therefore it can be inferred that CHS and its regulation factors are potential targets of anti-fungal therapy. This article reviews the recent research progress on classification, function, and regulation of CHS, and discusses the possibilities of using CHS and its regulation factors as anti-fungal targets.
