Sesquiterpenoids from the heartwood of Juniperu s chinensis.
10.20307/nps.2017.23.3.208
- Author:
Hee Jin JUNG
1
;
Byung Sun MIN
;
Hyun Ah JUNG
;
Jae Sue CHOI
Author Information
1. Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of Korea. choijs@pknu.ac.kr
- Publication Type:Original Article
- Keywords:
Juniperus chinensis;
3-Oxocedran-8β-ol;
Valenc-1(10),3(4),11(12)-trien-2-one;
11-Hydroxy-valenc-1(10),3(4)-dien-2-one;
Acetylcholinesterase;
Butyrylcholinesterase
- MeSH:
Acetylcholinesterase;
Butyrylcholinesterase;
Juniperus;
Magnetic Resonance Spectroscopy
- From:Natural Product Sciences
2017;23(3):208-212
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC₅₀ value of 68.45 µM.
