A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots.
10.20307/nps.2017.23.3.213
- Author:
Sang Yeol PARK
1
;
Nara LEE
;
SunKyoung LEE
;
Myong Jo KIM
;
Wanjoo CHUN
;
Hyun Pyo KIM
;
Hee Jung YANG
;
Ho Sun LEE
;
Yongsoo KWON
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea. yskwon@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Heracleum moellendorffii;
Angular furanocoumarins;
(3S, 4R)-3;
4-epoxypimpinellin;
Acetylcholinesterase inhibition
- MeSH:
Acetylcholinesterase;
Cholinesterase Inhibitors;
Coumarins;
Heracleum*;
Methods;
Plants
- From:Natural Product Sciences
2017;23(3):213-216
- CountryRepublic of Korea
- Language:English
-
Abstract:
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.
