Comparison of diagnosis efficacies between real-time tissue elastography and serum markers for liver cirrhosis
10.3724/SP.J.1008.2015.00957
- Author:
Meng-Lin ZHENG
1
Author Information
1. Department of Ultrasound, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Elasticity imaging techniques;
Liver cirrhosis;
Serologic tests
- From:
Academic Journal of Second Military Medical University
2015;36(9):957-960
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnosis efficacies between real-time tissue elastography (RTE) technique and serum markers for liver cirrhosis, and to explore non-invasive diagnosis methods for liver cirrhosis. Methods The clinic data of 124 patients who underwent liver resection or liver biopsy were analyzed retrospectively. Pathological results, RTE data and tests of serum markers were collected. RTE was expressed by liver fibrosis index (LFI). Tests of serum markers were divided into direct and indirect indicators. Direct indicators were four liver fibrosis detection (liver fibrosis four), including hyaluronic acid (HA), laminin (LN), typeIII procollagen amino peptide (PCIII), and type IV collagen (IV-C). Indirect indicators were the ratio of aspartate aminotransferase to platelet (AST-to-platelet ratio index, APRI). Pathology results served as the gold standard, and diagnostic values of RTE and serum markers for cirrhosis were compared by a receiver operating characteristics (ROC) curve analysis. Results Ninety-three (75.0%) of the 124 patients had no cirrhosis and 31 (25.0%) had cirrhosis. With pathological results as the gold standard, the sensitivity of HA was 67.7%, the specificity of HA was 62.4%, and the accuracy of HA was 63.7%; the sensitivity of APRI was 80.6%, the specificity of APRI was 49.5%, and the accuracy of APRI was 58.3%; and the sensitivity of LFI was 93.5%, the specificity of LFI was 71.0%, and the accuracy of LFI was 76.6%. Conclusion LFI, HA, and APRI index all have diagnostic values for liver cirrhosis, in which LFI detected by RTE has the highest diagnostic efficacy and ARPI is of high specificity but low sensitivity.
