Association of serum HER-2 level with metabolic syndrome in middle-aged and elderly population
10.3724/SP.J.1008.2015.00518
- Author:
Li QIN
1
Author Information
1. Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiaotong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Aged;
HER-2;
Metabolic syndrome;
Middle aged;
Proto-oncogenes
- From:
Academic Journal of Second Military Medical University
2015;36(5):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of circulating HER-2 level with metabolic syndrome in middle-aged and elderly population. Methods We conducted a population-based cross-sectional study with 687 participants aged 40 years or older from a community in Chongming District, Shanghai, China. Serum HER-2 levels were measured using ELISA. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adutt Treatment Panel III (NCEP ATP III) criteria for Asian-Americans. Results After adjusting for other influencing factors, we found that the participants with metabolic syndrome (n=370) had significantly higher HER-2 level compared with the control group (n=317) ([12. 4 ± 2. 3] ng/mL vs [8. 2 ± 1. 6] ng/mL, P<0. 001). The serum HER-2 level increased (P<0. 001) with the accumulation of the metabolic syndrome components. After adjusting for potential risk factors, multiple logistic regression analysis showed that the highest quartile of serum HER-2 was associated with increased risk of metabolic syndrome, with a fully adjusted odds ratio (OR) of 1. 35 (95' confidence interval [CI] - 1. 14-2. 31), P<0. 001). Conclusion Serum HER-2 is independently associated with metabolic syndrome in middle-aged and elderly Chinese in this study.
