Antioxidant Vitamins and Lipid Peroxidation in Patients with Cervical Intraepithelial Neoplasia.
10.3346/jkms.2005.20.2.267
- Author:
Geum Ju LEE
1
;
Hwan Wook CHUNG
;
Ki Heon LEE
;
Hong Seok AHN
Author Information
1. Department of Food and Nutrition, Sungshin Women's University, Seoul, Korea. hsahn@sungshin.ac.kr
- Publication Type:Original Article
- Keywords:
Cervical Intraepithelial Neoplasia;
Antioxidants;
Vitamins;
Lipid Peroxidation
- MeSH:
Adult;
Aged;
Antioxidants/administration & dosage/*metabolism;
Cervical Intraepithelial Neoplasia/*metabolism;
Cervix Neoplasms/*metabolism;
Energy Intake;
Female;
Humans;
*Lipid Peroxidation;
Middle Aged;
Vitamins/administration & dosage/*blood
- From:Journal of Korean Medical Science
2005;20(2):267-272
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate the implications of dietary intake and the level of plasma antioxidant, lipid peroxidation, and antioxidant capacity in Korean women with cervical intraepithelial neoplasia (CIN). From October 2002 to March 2003, 58 patients diagnosed with CIN (confirmed with colposcopy directed biopsy) and 86 patients without any cervical disease as control group were enrolled in the study at the Department of Gynecology cancer center at Samsung Cheil Hospital. The intake of antioxidant vitamins in both groups exceeded the amount recommended by the Korea RDA, 7th edition. The plasma concentration of Vitamin C was significantly lower in the CIN group (0.36 mg/dL) than in the control group (0.48 mg/dL) (p<0.05). The two groups showed similar plasma concentrations of beta-carotene, alpha-tocopherol, and retinol. The average concentration of malondialdehydes in the CIN group, 7.23 mmol/mL, was significantly higher than in the control group, 5.18 mmol/mL (p<0.01). The total radical trapping antioxidant potential concentration of plasma was significantly higher in the CIN group (1.15 mM) than in the control group (1.25 mM) (p<0.05). These results suggest that there is a possible correlation between cervical intraepithelial neoplastic processes and changes in the plasma antioxidative system.
