Clinical controlled study of laparoscopic and open resection for gastrointestinal stromal tumors of stomach: A single center experience
10.16781/j.0258-879x.2016.07.0905
- Author:
Xu-Guang HUANG
1
Author Information
1. Department of Gastrointestinal Surgery, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Laparoscopic surgery;
Open surgery;
Outcome;
Stomach neoplasms
- From:
Academic Journal of Second Military Medical University
2016;37(7):905-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacies between open resection and laparoscopic resection for gastrointestinal stromal tumors (GISTs) of stomach, and to discuss the indications of laparoscopic resection for GISTs. Methods A retrospective analysis was conducted in 174 patients with GISTs undergoing either open (open resection group [ORG], n = 76) or laparoscopic resection (laparoscopic resection group [LRG], n=98) from July 2008 to April 2014 at Changhai Hospital. The patients, according to tumor size (max diameter), were divided into two subgroups: <5 cm (113 cases: 35 cases for ORG and 78 cases for LRG), ≥5 cm and ≤10 cm (61 cases: 41 cases for ORG and 20 cases for LRG). The data for analysis included gender, age, tumor size, risk grading, mitotic rate, surgical type, operative time, intraoperation blood loss, postoperative hospital stay, postoperative feeding time, and 5-year tumor-free survival time, etc. Results The gender, age, tumor size, risk grading, mitotic rate and surgical type of patients had no significant differences between the laparoscopic and open resection groups for the two tumor size groups. When the tumor size <5 cm, the operation time was similar for the two surgical approaches, but the blood loss, postoperative hospital stay and postoperative feeding time were significantly reduced in LRG compared with ORG (P<0. 01). When the tumor size ≥5 cm and ≤10 cm, the operation time and postoperative hospital stay were similar between ORG and LRG, but the blood loss and postoperative feeding time of LRG were significantly less than those of ORG (P<0. 05). The 5-year tumor-free survival time was not significantly different between LRG and ORG for the two tumor size groups. Conclusion When the tumor size is <5 cm, laparoscopic resection is more safe and reliable than open resection for the gastrointestinal stromal tumor of stomach; when the tumor size is ≥5 cm and ≤10 cm, laparoscopic resection is safe and feasible after appropriate preoperative evaluation and patient selection.
