Irisin and type 2 diabetes mellitus in the elderly
10.16781/j.0258-879x.2016.01.0072
- Author:
Xiang-Qin HUANG
1
Author Information
1. Department of Endocrinology, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Beige fat;
Brain-derived neurotrophic factor;
Fibronectin type III domain containing protein 5;
Irisin aged;
Telomere;
Type 2 diabetes mellitus
- From:
Academic Journal of Second Military Medical University
2016;37(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Irisin is a newly discovered myogenic glycosylation of peptide which can promote expression of uncoupling protein in white fat cells, facilitate lipid droplet formation, increase mitochondrial density and oxygen consumption of fat cells, and results in the shift from white fat cells to brown fat cells and promotion of β cells regeneration, thus inhibiting the occurrence of obesity and insulin resistance. Meanwhile, Irisin can also increase brain-derived neurotrophic factor, activate genes involved in learning and memorizing, so as to improve cognition function. Furthermore, Irisin is also reported to mitigate aging by extending the length of telomeres. This paper reviewed the relationship between Irisin and type 2 diabetes in the elderly, hoping to provide reference for prevention and treatment of type 2 diabetes in the elderly.
