Role of hypoxia-inducible factors in ischemia/reperfusion injury: An update
10.16781/j.0258-879x.2016.04.0488
- Author:
Hong-Zhe TIAN
1
Author Information
1. Department of Organ Transplantation, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypoxia-inducible factors;
Ischemia;
Reperfusion injury
- From:
Academic Journal of Second Military Medical University
2016;37(4):488-492
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia/reperfusion injury (IRI) is a common clinical pathophysiological process characterized by ischemia and hypoxia. Hypoxia-inducible factors (HIFs) are a group of transcription factors vital to cell responding and adapting to hypoxia environment. Hypoxia can activate HIF, thus enhancing the tolerance of cells to hypoxia. The role of HIF in IRI has become a research focus of many scientists. Elucidating the related mechanism can not only help to reduce IRI, but also lay a basis for further studying the role of HIF in other pathophysiological processes. In this paper, we reviewed the structure, function of HIF and the specific role and related mechanisms of HIF in IRI.
