Problems and countermeasures in liver stem cell research and application
10.16781/j.0258-879x.2017.09.1092
- Author:
Yong LIN
1
Author Information
1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Chronic liver diseases;
Liver stem cells;
Stem cell markers;
Stem cell transplantation
- From:
Academic Journal of Second Military Medical University
2017;38(9):1092-1097
- CountryChina
- Language:Chinese
-
Abstract:
Stem cell has been one of the focuses in current biomedical research. It has been well documented that there are various liver stem cells (LSCs) with different markers in liver, and they play important roles in liver regeneration. Moreover, some progresses have been made in autologous and allogeneic stem cells transplantation for the treatment of end-stage liver diseases. However, the origin and markers of LSCs have not been fully clarified, and the mechanism involved in LSCs proliferation and differentiation remains to be deeply studied. With the improvements of lineage tracing technique and stem cell isolation and culture system, it is believed that the origin of LSCs and their role in liver regeneration will be further clarified, and LSCs treatment for liver diseases will soon become a reality.
