Network pharmacological studies of Guanxin Qiwei tablet in treating coronary heart disease
10.16781/j.0258-879x.2017.08.1075
- Author:
Shu-Guang YAN
1
Author Information
1. Department of Formulaology, Shaanxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Guanxin Qiwei tablet;
Network pharmacology;
Targets
- From:
Academic Journal of Second Military Medical University
2017;38(8):1075-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the active ingredients of Guanxin Qiwei tablet, and to explore the potential target for its efficacy. Methods We studied the interaction between Chinese medicine ingredients in the Guanxin Qiwei tablet and the therapy targets using a network pharmacology model, which was developed by integrating oral bioavailability prediction, druggability analysis, principal component analysis, molecular docking simulation and network of pharmacophore-target-disease analysis. Results Eighteen principal compounds had high-degree network with 41 therapy targets for coronary heart disease (CHD), and had higher affinity with 18 potential targets via the calculation of molecular docking. Further analysis showed that 7 key targets were closely related to the treatment of CHD. Conclusion We have screened 18 possible active molecules in Guanxin Qiwei tablet and 7 key therapy targets, and preliminarily elucidate the molecular mechanism based on the “multi-ingredient, multi-target, and synergistic effect”.
