A Case of Cerebral Infarct in Combined Antiphospholipid Antibody and Ovarian Hyperstimulation Syndrome.
10.3346/jkms.2002.17.4.574
- Author:
Eun Jung KOO
1
;
Joung Ho RHA
;
Byoung Ick LEE
;
Myeong Ok KIM
;
Choong Kun HA
Author Information
1. Department of Neurology, Inha University Medical College, Inchon, Korea. jhrha@inha.ac.kr
- Publication Type:Case Reports
- Keywords:
Antiphospholipid Syndrome;
Ovarian Hyperstimulation Syndrome;
Cerebrovascular Disorders
- MeSH:
Adult;
Antibodies, Anticardiolipin/blood;
Antiphospholipid Syndrome/*complications/pathology;
Female;
Humans;
Iatrogenic Disease;
Infarction, Middle Cerebral Artery/*etiology/pathology;
Magnetic Resonance Angiography;
Ovarian Hyperstimulation Syndrome/*complications/pathology;
Ovulation Induction;
Pregnancy;
*Pregnancy Complications/pathology
- From:Journal of Korean Medical Science
2002;17(4):574-576
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ovarian hyperstimulation syndrome is a serious complication of ovulation induction and has a diverse clinical spectrum from edema to thromboembolism. Antiphospholipid antibody syndrome, one of the well known hypercoagulable states, can be also manifested as an arterial or venous thrombosis and recurrent spontaneous abortion. Sometimes a patient with antiphospholipid antibodies might not notice a miscarriage and seek for assisted reproduction treatment, which harbors a chance of developing ovarian hyperstimulation syndrome. If this happens, the ovarian hyperstimulation syndrome can exacerbate the thrombotic complication of underlying antiphospholipid antibody syndrome, resulting in a catastrophic vascular event. The authors experienced a case of middle cerebral artery infarct, which developed during ovarian hyperstimulation syndrome in a 33-yr-old woman with a previous history of fetal loss. An elevated titer of anticardiolipin antibodies was noticed and persisted thereafter. The authors suggest screening tests for the presence of antiphospholipid antibodies before controlled ovarian hyperstimulation.
