Research progress of cell-penetrating peptides in tumor-targeted therapy
10.16781/j.0258-879x.2017.06.0774
- Author:
Chun-Ai GONG
1
Author Information
1. Department of Pharmacy, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Cell penetrating peptides;
Nanomedicine;
Neoplasmas;
Targeted therapy
- From:
Academic Journal of Second Military Medical University
2017;38(6):774-779
- CountryChina
- Language:Chinese
-
Abstract:
Advances in biotechnology give much importance to the therapeutic biomacromolecules in the therapy of diseases, such as proteins, oligonucleotides, and peptides. But their effects are limited in practical application because of cell membrane barrier. Cell-penetrating peptides (CPPs) are promising oligopeptides with a remarkable capacity for membrane translocation, which can carry various macromolecules into cells. In this paper, we reviewed the classification and transmembrane mechanism of CPPs as nanoparticles, with particular focus on their recent progress in tumor-targeted therapy.
