Hypoxia inducible factor in postmenopausal osteoporosis: Recent progress
10.16781/j.0258-879x.2017.04.0458
- Author:
Lin WANG
1
Author Information
1. Department of Orthopaedic Trauma, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Bone resorption;
Hypoxia inducible factors;
Osteogenesis;
Osteoporosis
- From:
Academic Journal of Second Military Medical University
2017;38(4):458-462
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor (HIF) plays a key role in the cellular response to hypoxia, and is involved in a variety of pathological and physiological processes such as glucose metabolism, vascular remodeling and erythropoiesis. Growing research suggests that HIF has an important effect on osteogenesis, bone resorption and angiogenesis; while the deterioration of bone vascular structures and functions is closely related to the development and progression of postmenopausal osteoporosis. In this review, we summarized the relationship between HIF and postmenopausal osteoporosis based on the roles of HIF in osteogenesis, bone resorption and angiogenesis, hoping to evaluate its therapeutic prospect on postmenopausal osteoporosis.
