Intravenous thrombolysis for acute ischemic stroke: New evidence and focus
10.16781/j.0258-879x.2018.09.0959
- Author:
Ben-Qiang DENG
1
Author Information
1. Stroke Center, Changhai Hospital, Navy Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Intravenous thrombolytic therapy;
Low-dose;
Recombinant tissue plasminogen activator;
Tenecteplase
- From:
Academic Journal of Second Military Medical University
2018;39(9):959-964
- CountryChina
- Language:Chinese
-
Abstract:
Acute ischemic stroke (AIS) has the characteristics of high morbidity, disability and mortality. Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) for AIS in time window is an effective treatment recommended by domestic and overseas guidelines. However, intravenous thrombolysis has shortcomings, such as short time window, low recanalization rate and high risk of bleeding. Therefore, in recent years, studies on prolonging the time window, using low-dose rt-PA or a new generation of thrombolytic agent, and thrombolysis combined with anti-thrombotic therapy have been carried out worldwide. Based on the studies on intravenous thrombolysis, this paper discusses several issues, including extending time window, low-dose rt-PA thrombolysis, and new generation of thrombolytic agent.
