Long non-coding RNAs in development and progression of cervical cancer: Mechanism research status
10.16781/j.0258-879x.2019.10.1124
- Author:
Hai-Wei HE
1
Author Information
1. Department of Gynaecology and Obstetrics, Changhai Hospital, Naval Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Long non-coding RNAs;
MicroRNAs;
Signaling pathway;
Uterine cervical neoplasms
- From:
Academic Journal of Second Military Medical University
2019;40(10):1124-1129
- CountryChina
- Language:Chinese
-
Abstract:
Cervical cancer is the second most commonly seen cancer in women and the third leading cause of cancer death in developing countries. Early diagnosis and treatment are the keys to the effective treatment of cervical cancer and the improvement of prognosis. Because of the complexity, the mechanism of development and progression of cervical cancer is still an urgent problem to solve. Recently, quantity of studies have shown that long non-coding RNAs (lncRNAs) play important roles in tumor development and progression. In this review, we sumed up the multiple effects of lncRNAs in cervical cancer, focusing on the related mechanisms of human papilloma virus (HPV) E6 and E7 oncoprotein, the nature of lncRNAs and the signaling pathway in the development and progression of cervical cancer. And we further expounded the cervical cancer mechanism network, providing reference for screening the potential markers for early diagnosis and treatment of cervical cancer.
