Comparison of cytokine expression profiles in infants with a rhinovirus induced lower respiratory tract infection with or without wheezing: a comparison with respiratory syncytial virus.
10.3345/kjp.2017.60.9.296
- Author:
Da Eun ROH
1
;
Sook Hyun PARK
;
Hee Joung CHOI
;
Yeo Hyang KIM
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. kimyhmd@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Cytokine;
Infant;
Respiratory syncytial virus;
Rhinovirus
- MeSH:
Humans;
Infant*;
Interferon-gamma;
Interleukin-10;
Interleukin-12;
Interleukin-13;
Interleukin-4;
Interleukin-5;
Interleukins;
Polymerase Chain Reaction;
Respiratory Sounds*;
Respiratory Syncytial Viruses*;
Respiratory System*;
Respiratory Tract Infections*;
Reverse Transcription;
Rhinovirus*
- From:Korean Journal of Pediatrics
2017;60(9):296-301
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to evaluate whether infants with rhinovirus (RV) infection-induced wheezing and those with respiratory syncytial virus (RSV) infection-induced wheezing have different cytokine profiles in the acute stage. METHODS: Of the infants with lower respiratory tract infection (LRTI) between September 2011 and May 2012, 88 were confirmed using reverse transcription polymerase chain reaction and hospitalized. Systemic interferon-gamma (IFN-γ), interleukin (IL)-2, IL-12, IL-4, IL-5, IL-13, and Treg-type cytokine (IL-10) responses were examined with multiplex assay using acute phase serum samples. RESULTS: Of the 88 patients, 38 had an RV infection (RV group) and 50 had an RSV infection (RSV group). In the RV group, the IFN-γ and IL-10 concentrations were higher in the patients with than in the patients without wheezing (P=0.022 and P=0.007, respectively). In the RSV group, the differences in IFN-γ and IL-10 concentrations did not reach statistical significance between the patients with and the patients without wheezing (P=0.105 and P=0.965, respectively). The IFN-γ and IL-10 concentrations were not significantly different between the RV group with wheezing and the RSV group with wheezing (P=0.155 and P=0.801, respectively), in contrast to the significant difference between the RV group without wheezing and the RSV group without wheezing (P=0.019 and P=0.035, respectively). CONCLUSION: In comparison with RSV-induced LRTI, RV-induced LRTI combined with wheezing showed similar IFN-γ and IL-10 levels, which may have an important regulatory function.
