Design of novel micellar nano-traditional Chinese medicine formulations based on anti-tumor mechanisms of traditional composition
10.16781/j.0258-879x.2019.08.0821
- Author:
Ruo-Chen HUANG
1
Author Information
1. Graduate School, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Antineoplastic drugs (TCD);
Compounds (TCD);
Micellar nano-formulation of traditional Chinese medicine;
Nanotechnology
- From:
Academic Journal of Second Military Medical University
2019;40(8):821-826
- CountryChina
- Language:Chinese
-
Abstract:
Clinically traditional Chinese medicine (TCM) has been proven to possess obvious anti-tumor effects. It is critical to further explore the effective components and the corresponding mechanism of the TCM against target cells, which also has great significance for developing novel nano-TCM formulations for clinical treatment of tumor. This paper systematically reviews the anti-tumor effects of Chinese herbal compound and the anti-tumor mechanism of single herb. We also summarized the progress in the current traditional nano-TCM preparations. Taking the shikonin in Herba Arnebiae as an example, using the nano-material self-assembly technology, we discussed the design of novel nano-macromolecule TCM formulations while considering the mechanism of single herb and the clinical obstacles.
