Advances in pharmacogenomics of new oral anticoagulants
10.16781/j.0258-879x.2020.05.0558
- Author:
An-Ni CHEN
1
Author Information
1. Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Gene polymorphisms;
Metabolic enzymes;
New oral anticoagulants;
Pharmacogenomics;
Pharmacokinetics;
Transport system
- From:
Academic Journal of Second Military Medical University
2020;41(5):558-563
- CountryChina
- Language:Chinese
-
Abstract:
Novel oral anticoagulants (NOACs) play an important role in the prevention and treatment of cardiovascular and cerebrovascular thrombosis. Different individuals have different pharmacokinetic parameters in vivo after taking the same dose of NOACs, which may be related to gene polymorphisms of transporters and metabolic enzymes involved in the in vivo process of NOACs. Compared with drug transporters, gene polymorphisms of drug metabolizing enzymes have a greater impact on the pharmacokinetic properties of NOACs, but there have been few related studies up to now. In this paper we summarized the effects of gene polymorphisms on the pharmacokinetic properties of NOACs..
