Efficacy and toxicity analysis of domestic and imported precision radiotherapy equipment in the treatment of lymphoma
10.16781/j.0258-879x.2020.05.0527
- Author:
Xia-Nan LI
1
Author Information
1. Department of Radiotherapy, Peking University, People s Hospital
- Publication Type:Journal Article
- Keywords:
Domestic equipment;
Imported equipment;
Lymphoma;
Precision radiotherapy
- From:
Academic Journal of Second Military Medical University
2020;41(5):527-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the advantages and disadvantages of domestic precision radiotherapy equipment by comparing the clinical efficacies of domestic and imported precision radiotherapy equipments in the treatment of lymphoma. Methods We investigated the treatments of lymphoma in hospitals of different levels using domestic and imported medical linear accelerators and divided them into domestic and imported groups. The data of patients in the two groups were retrospectively analyzed, and the radiotherapy equipment brand, short-term efficacy, acute toxicity, dosimetric parameters of organs at risk and the costs of radiation therapy were compared between the two groups. Results A total of 101 cases receiving radiation therapy for lymphoma in 10 hospitals were collected, including 77 cases in the imported group and 24 cases in the domestic group. The overall response rates were high in both groups, being 88.3% (68/77) in the imported group and 87.5% (21/24) in the domestic group, with no significant difference (P=1.00). The incidences of hematological toxicity (>grade 2) were low in both groups, being 1.3% (1/77) vs 8.3% (2/24), with no significant difference (P=0.14). Subgroup analysis was performed on the dosimetric parameters of organs at risk and acute toxicity of the two groups for extranodal nasal type NK/T cell lymphoma, and there were no significant differences in the maximal dose (Dmax) of the lens, Dmaxof the optic nerve, or mean dose (Dmean) of the parotid gland between the two groups (all P>0.05). However, there was an increasing trend in the domestic group compared with the imported group for Dmeanof bilateral parotid gland (left: [2 306.53±1 119.66] cGy vs[ 1 279.44±1 026.95] cGy, P=0.16; right:[ 2 328.35±1 009.76] cGy vs[ 1 303.79±1 116.79] cGy, P=0.17). The incidence of grade 2 xerostomia in the domestic group was higher than that in the imported group, but the difference was not statistically significant (50.0%[ 2/4] vs 14.3%[ 1/7], P>0.05). The domestic group had significantly lower radiotherapy cost [( 26 743.9±8 061.2] yuan vs[ 42 428.7±14 744.7] yuan) and total hospitalization cost [( 36 702.1± 12 225.8] yuan vs[ 50 192.7±15 494.4] yuan) than the imported group (both P<0.01). Conclusion There is no significant difference in the short-term efficacy of lymphoma treatment between the domestic radiotherapy equipment and the imported radiotherapy equipment, while the treatment cost of the domestic radiotherapy equipment is relatively low. However, the dosimetric parameters of organs at risk of imported radiotherapy equipment is lower and the acute toxicity is less..