Recent vaccine technology in industrial animals.
- Author:
Hyunil KIM
1
;
Yoo Kyoung LEE
;
Sang Chul KANG
;
Beom Ku HAN
;
Ki Myung CHOI
Author Information
- Publication Type:Review
- Keywords: Vaccines; Virus-like particle vaccines; Porcine circovirus; Venezuelan equine encephalitis virus; Porcine epidemic diarrhea virus
- MeSH: Alphavirus; Animal Diseases; Animals*; Circovirus; Communicable Diseases; Diarrhea; Encephalitis Virus, Venezuelan Equine; Encephalomyelitis, Equine; Immunity, Cellular; Porcine epidemic diarrhea virus; RNA; Vaccines; Vaccines, Synthetic; Vaccines, Virus-Like Particle; Venezuela
- From:Clinical and Experimental Vaccine Research 2016;5(1):12-18
- CountryRepublic of Korea
- Language:English
- Abstract: Various new technologies have been applied for developing vaccines against various animal diseases. Virus-like particle (VLP) vaccine technology was used for manufacturing the porcine circovirus type 2 and RNA particle vaccines based on an alphavirus vector for porcine epidemic diarrhea (PED). Although VLP is classified as a killed-virus vaccine, because its structure is similar to the original virus, it can induce long-term and cell-mediated immunity. The RNA particle vaccine used a Venezuela equine encephalitis (VEE) virus gene as a vector. The VEE virus partial gene can be substituted with the PED virus spike gene. Recombinant vaccines can be produced by substitution of the target gene in the VEE vector. Both of these new vaccine technologies made it possible to control the infectious disease efficiently in a relatively short time.
