Cytokine storm and immunoregulatory therapy of coronavirus pneumonia
10.16781/j.0258-879x.2020.07.0701
- VernacularTitle: 冠状病毒肺炎细胞因子风暴及免疫调控治疗
- Author:
Ting WANG
1
Author Information
1. Department of Anesthesiology, Changhai Hospital, Naval Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Camostat mesylate;
Coronavirus infections;
Cytokine storm;
Granulocyte colony-stimulating factor;
Pneumonia;
Tocilizumab
- From:
Academic Journal of Second Military Medical University
2020;41(7):818-823
- CountryChina
- Language:Chinese
-
Abstract:
Cytokine storm, a runaway overwhelming immune response, plays an important part in the pathogenesis of coronavirus. The virus hijacks the immune system, resulting in a loss of negative feedback on the immune regulation and an overproduction of inflammatory cytokines, which subsequently impairs the pulmonary diffusion function and leads to multiorgan dysfunction. A series of progresses have been achieved in studies targeting the coronavirus cytokine storm, such as granulocyte colony-stimulating factor, tocilizumab, camostat mesylate, and blood purification treatment, which may provide effective ways to alleviate the coronavirus disease 2019 (COVID-19) epidemic. Nevertheless, further clinical verifications of the above research findings are requested due to the unique pathology of COVID-19. This paper reviews the advances in cytokine storm and immunoregulatory therapy of coronavirus pneumonia.
