Insulin nanoparticles with high oral bioavailability: Research progress
10.16781/j.0258-879x.2020.09.1027
- Author:
Si-Qi WANG
1
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Drug delivery system;
Insulin;
Nanoparticles
- From:
Academic Journal of Second Military Medical University
2020;41(9):1027-1030
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a chronic metabolic disease characterized by changes in the dynamic balance of blood glucose levels. Subcutaneous injection of insulin is a first-line treatment for diabetes. However, patient compliance is poor due to pain, discomfort, and local infection. Oral administration is convenient and safe, but the existing oral insulin preparations still need to be optimized due to gastrointestinal instability and poor bioavailability. The rapid development of nanopreparation technology provides a solid foundation for improving the bioavailability of oral insulin preparations and achieving the effective oral delivery of insulin. This paper reviews the research progress in insulin nanoparticles with high oral bioavailability in recent years.
