Micro-CT analysis of hyperuricemia on alveolar bone destruction caused by short-term periodontal infection in mice
10.12016/j.issn.2096⁃1456.2021.02.003
- Author:
LUO Yongxi
1
;
HUANG Xueying
1
;
XIAN Ruoting
1
;
YU Wanxin
1
;
LIANG Lixin
1
;
LIANG Zhaojia
1
;
CHEN Ziyun
1
;
HOU Dan
1
;
YU Ting
1
Author Information
1. Stomatology Hospital of Guangzhou Medical University, Key Laboratory of Oral Medicine, Guang⁃ zhou Institute of Oral Disease
- Publication Type:Journal Article
- Keywords:
hyperuricemia;
uric acid;
periodontitis;
murine model;
alveolar bone resorption;
micro-CT;
bone volume fraction;
bone mineral density
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(2):88-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Establish a murine model for hyperuricemia (HU) and periodontitis to explore whether there is correlation between them and provide a basis for periodontal treatment.
Methods:Fourteen male KM mice were divided into 2 groups; the HU group (n=7) was fed food supplemented with potassium oxonate and uric acid, the NC group (n=7) was fed standard food, and the induction period was 35 days. On the 25th day, the molars on one side were ligated to induce periodontitis (P side), while the opposite was true for the control (C side). Baseline and terminal serum uric acid (UA) levels were detected, and alveolar bone resorption was analyzed by micro-CT.
Results:The serum UA level of HU mice was (112.94 ± 26.82 )mol/L, that of the NC group was (72.21 ± 19.95) μmol/L, and the difference in UA level was statistically significant (P < 0.05). The P side bone volume fractions of the HU and NC groups were( 29.01 ± 11.09)% and (29.56 ± 15.27)%, respectively, which were not significantly different (t=-0.072, P=0.944). The P side bone mineral densities of the HU and NC groups were(0.53 ± 0.16) g/cm3 and (0.52 ± 0.14) g/cm3, respectively, which were not significantly different (t=0.038, P=0.970). Additionally, there was no correlation between HU or serum UA and alveolar bone resorption (P > 0.05).
Conclusion :This research established a murine model for HU and periodontitis, but based on micro-CT analysis of alveolar bone, no relationship between HU or UA levels and periodontitis was found.
- Full text:高尿酸血症对小鼠短期牙周感染牙槽骨破坏的micro-CT分析.pdf
