Identification and diagnostic value of characteristic volatile organic compounds in exhaled breath of patients with early stage lung cancer
- VernacularTitle:早期肺癌患者呼出气特征性挥发性有机化合物及其诊断价值研究
- Author:
Xiaoqin PENG
1
;
Mingxin LIU
2
,
3
;
Wei DAI
2
;
Shaohua XIE
2
;
Run XIANG
2
;
Fengyi ZHANG
4
;
Qiang LI
2
Author Information
1. Department of Oncology, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, 637000, Sichuan, P.R.China
2. Department of Thoracic Surgery, Sichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, P.R.China
3. 3. School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, P.R.China
4. Department of Thoracic Surgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, 637000, Sichuan, P.R.China
- Publication Type:Journal Article
- Keywords:
Lung cancer;
early diagnosis;
exhaled breath;
volatile organic compounds;
diagnostic model
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(12):1429-1435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristic volatile organic compounds (VOCs) in exhaled breath and their diagnostic value in patients with early stage lung cancer. Methods Solid-phase micro-extraction combined with gas chromatography mass spectrometry was used to analyze exhaled breath VOCs of 117 patients with early stage lung cancer (54 males and 63 females, with an average age of 61.9±6.8 years) and 130 healthy subjects (79 males and 51 females, with an average age of 63.3±6.6 years. The characteristic VOCs of early stage lung cancer were identified, and a diagnostic model was established. Results Ten characteristic VOCs of early stage lung cancer were identified, including acetic acid, n-butanol, dimethylsilanol, toluene, 2,3,4-trimethylheptane, 3,4-dimethylbenzoic acid, 5-methyl-3-hexene-2-ketone, n-hexanol, methyl 2-oxoglutarate and 4-methoxyphenol. Gender and the 10 characteristic VOCs were included in the diagnostic model, with a sensitivity of 83.8% and a specificity of 96.2%. Conclusion Analysis of exhaled breath VOCs is expected to be one of the potential methods used for early stage lung cancer diagnosis.
