Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase.
10.4168/aard.2015.3.4.288
- Author:
Da Hye YOON
1
;
Sung Hee KANG
;
Hwan Soo KIM
;
Jae Wook LEE
;
Jong Seo YOON
;
Nack Gyun CHUNG
;
Bin CHO
Author Information
1. Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul, Korea. tibia78@nate.com
- Publication Type:Original Article
- Keywords:
Asparaginase;
Drug hypersensitivity;
Premedication;
Immunologic desensitization;
Acute lymphoblastic leukemia
- MeSH:
Asparaginase;
Desensitization, Immunologic;
Drug Hypersensitivity;
Erwinia;
Humans;
Hypersensitivity*;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Premedication*;
Urticaria
- From:Allergy, Asthma & Respiratory Disease
2015;3(4):288-293
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use. METHODS: We performed 44 cases of premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase. RESULTS: With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reactions. Eleven cases showed mild hypersensitivity reactions, such as urticaria. Desensitization was performed in 3 cases: in 2 cases, desensitization was successful, and in 1 case the medication was switched to Erwinia asparaginase. CONCLUSION: Premedication and desensitization appear to be useful in helping patients receive desired doses of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.
