Research advances in the role of myeloid-derived suppressor cells in liver diseases
DOI:10.3969/j.issn.1001-5256.2020.12.045
- VernacularTitle:骨髓来源抑制性细胞在肝脏疾病中的研究进展
- Author:
Lijun XU
1
;
Xiuqin AN
;
Yue LI
;
Jinchun LIU
Author Information
1. Graduate School of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
liver diseases;
myeloid cells;
myeloid progenitor cells
- From:
Journal of Clinical Hepatology
2020;36(12):2851-2855
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, more and more studies have shown that myeloid-derived suppressor cells (MDSCs) participate in the development and progression of various chronic liver diseases including chronic viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune liver diseases, and liver cancer. As a type of cells derived from bone marrow progenitor cells and immature myeloid cells, MDSCs play an important role in the development, progression, and repair of liver diseases by regulating inflammatory response and the differentiation and function of immune cells. This article reviews the research advances in the association between MDSCs and various liver diseases, in order to provide new thoughts for the clinical diagnosis, prognosis, and treatment of chronic liver diseases.
