Role of pyroptosis in liver diseases
DOI:10.3969/j.issn.1001-5256.2020.12.044
- VernacularTitle:细胞焦亡在肝脏疾病中的作用
- Author:
Weisong XIAO
1
;
Yingyu LE
;
Shenglan ZENG
;
Xiaobin QIN
;
Cong WU
;
Chengyu YA
;
Dewen MAO
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning 530222, China
- Publication Type:Research Article
- Keywords:
pyroptosis;
liver disease;
inflammasome;
pathologic processes
- From:
Journal of Clinical Hepatology
2020;36(12):2847-2850
- CountryChina
- Language:Chinese
-
Abstract:
As a novel form of programmed cell death different from cell necrosis, apoptosis, and autophagy discovered in recent years, pyroptosis is characterized by cell membrane rupture and release of cell contents and proinflammatory factors mediated by gasdermin, thus leading to cell death. Pyroptosis signaling pathways can be classified into classical pathways dependent on caspase-1 and non-classical pathways dependent on caspase-4/5/11; the activation of caspase-1 in classical pathways depends on the function of inflammasome, while the direct activation of caspase-4/5/11 is observed in non-classical pathways, which leads to the lysis of gasdermin D and induce the formation of membrane pores, the maturation and release of interleukin-1β and interleukin-18, and the rupture of cell membrane to cause pyroptosis. Latest research has shown that pyroptosis plays an important role in the development and progression of chronic liver diseases. This article introduces the mechanism of pyroptosis and summarizes the role of pyroptosis in the development and progression of nonalcoholic fatty liver disease, alcoholic liver disease, viral hepatitis, liver cirrhosis, and hepatocellular carcinoma, in order to provide new ideas and methods for the prevention and treatment of liver diseases in clinical practice.
