Application of circulating free DNA in the diagnosis and treatment of hepatocellular carcinoma
DOI:10.3969/j.issn.1001-5256.2020.12.041
- VernacularTitle:循环游离DNA在肝细胞癌诊断和治疗中的应用
- Author:
Yijian YANG
1
;
Bimang FU
;
Nan XIE
;
Fan CAO
;
Yingzhen SU
Author Information
1. Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
DNA, neoplasm;
biopsy;
polymerase chain reaction;
sequence analysis, DNA
- From:
Journal of Clinical Hepatology
2020;36(12):2835-2838
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma has a low early diagnostic rate, and there is a lack of highly sensitive and specific tumor markers. In recent years, fluid biopsy technique, represented by circulating free DNA (cfDNA), has become an auxiliary method for the diagnosis of cancer and has attracted more and more attention due to its advantages of noninvasiveness, convenience, and repeatability. With reference to the recent studies in China and foreign countries, this article summarizes and analyzes the advances in cfDNA in the diagnosis and treatment of hepatocellular carcinoma from the aspects of biological characteristics, detection techniques, and clinical application, so as to provide a basis for clinical diagnosis and treatment.
