Role of gut microbiota and bile acid pathway in nonalcoholic fatty liver disease
DOI:10.3969/j.issn.1001-5256.2020.12.040
- VernacularTitle:肠道菌群和胆汁酸通路在非酒精性脂肪性肝病发病中的作用
- Author:
Mengyuan SUN
1
;
Xiaoxing XIANG
Author Information
1. Yangzhou University Medical College, Yangzhou, Jiangsu 225009, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
gastrointestinal microbiome;
cholic acids;
pathologic processes
- From:
Journal of Clinical Hepatology
2020;36(12):2831-2834
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease is a group of diseases with unclear pathophysiological mechanism and is closely associated with metabolic syndrome. Bacterial components and metabolites produced by gut microbiota can regulate glucose and lipid metabolism, inflammatory response, and oxidative stress, and bile acids regulate immune function, energy metabolism, and material metabolism through various signaling pathways after activating their receptors. Gut microbiota and bile acids interact with each other through enterohepatic circulation, and the changes of their structure and function are involved in the development and progression of nonalcoholic fatty liver disease. This article reviews the effect of the homeostatic dysregulation of gut microbiota and bile acids and their interactions on nonalcoholic fatty liver disease.
