Research advances in T helper 17 cells in chronic inflammatory liver diseases
DOI:10.3969/j.issn.1001-5256.2020.12.034
- VernacularTitle:辅助性T淋巴细胞17在慢性炎症性肝病中的研究进展
- Author:
Jingshu YANG
1
;
Ning LI
Author Information
1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China）
- Publication Type:Research Article
- Keywords:
hepatitis, chronic;
Th17 cells;
cytokines
- From:
Journal of Clinical Hepatology
2020;36(12):2808-2810
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 (Th17) cells, differentiated from nave CD4+T cells, can secrete a series of cytokines including interleukin-17, interleukin-21, and interleukin-22 and are meanwhile regulated by a variety of cytokines and genes, playing an important role in various inflammatory diseases. Th17 cells are widely distributed in vivo and are associated with diseases in many systems. They are involved in the regulation of chronic inflammatory/autoimmune diseases by secreting pro-inflammatory factors and antagonizing the immunosuppressive effect of regulatory T cells. This article reviews the recent studies on the association between Th17 cells and the pathogenesis of various chronic inflammatory liver diseases, so as to provide a reference for scientific research and clinical treatment.
