Progress of researches on the interaction between parasitic infections and host cell autophagy
10.16250/j.32.1374.2019241
- VernacularTitle:寄生虫感染与宿主细胞自噬相互作用研究进展
- Author:
Yang WU
1
;
Hong-Ling REN
1
;
Shan-Shan XU
1
;
Yuan GAO
1
;
Yu CUI
1
Author Information
1. Department of Parasitology, Dalian Medical University, Dalian 116044, China
- Publication Type:Journal Article
- Keywords:
Parasite;
Autophagy;
Toxoplasma gondii;
Plasmodium;
Trypanosoma brucei;
Leishmania
- From:
Chinese Journal of Schistosomiasis Control
2020;32(6):654-656
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy, a conserved intracellular degradation system, is a specific life phenomenon in eukaryocytes. Autophagy is widely accepted as a pathway that double-membrane autophagosomes envelop and sequester intracellular cytoplasmic components and then fuse with lysosomes to form autolysosomes, which degrade their contents to regenerate nutrients. Autophagy may be triggered by starvation and a diverse range of pathogens, including parasites. Following infection with intracellular parasites, host cells may eliminate parasites by autophagy. However, parasites may develop self-defense mechanisms, and promote the self-growth and -development by host cell autophagy. This review describes the advances in the interplay between parasitic infections and host cell autophagy. Understanding autophagy is of great significance for the management of parasitic infections and the development of antiparasitic drugs.
