Hypernatremia increases the incidence of late delirium after cardiac surgery
- VernacularTitle:高钠血症增加心脏手术后晚发谵妄的发生率
- Author:
Liang HONG
1
;
Xiao SHEN
1
;
Chang SHU
1
;
Qiankun SHI
1
;
Xinwei MU
1
;
Cui ZHANG
1
Author Information
1. Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, P.R.China
- Publication Type:Journal Article
- Keywords:
Cardiac surgery;
hypernatremia;
postoperative delirium
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(11):1320-1325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze whether hypernatremia within 48 hours after cardiac surgery will increase the incidence of delirium which developed 48 hours later after surgery (late-onset delirium). Methods We conducted a retrospective analysis of 3 365 patients, including 1 918 males and 1 447 females, aged 18-94 ( 60.53±11.50) years, who were admitted to the Department of Cardiothoracic and Vascular Surgery of Nanjing First Hospital and underwent cardiac surgery from May 2016 to May 2019. Results A total of 155 patients developed late-onset delirium, accounting for 4.61%. The incidence of late-onset delirium in patients with hypernatremia was 9.77%, the incidence of late onset delirium in patients without hypernatremia was 3.45%, and the difference was statistically different (P<0.001). The odds ratio (OR) of hypernatremia was 3.028 (95% confidence interval: 2.155-4.224, P<0.001). The OR adjusted for other risk factors including elderly patients, previous history of cerebrovascular disease, operation time, cardiopulmonary bypass time, lactate, hemoglobin≥100 g/L, prolonged mechanical ventilation, left ventricular systolic function, use of epinephrine, use of norepinephrine was 1.524 (95% confidence interval: 1.031-2.231, P=0.032). Conclusion Hypernatremia within 48 hours after cardiac surgery may increase the risk of delirium in later stages.
