Three butylphthalide derivatives from the Rhizome of Ligusticum chuanxiong
10.16438/j.0513-4870.2020-0887
- VernacularTitle:川芎中三个新的丁基苯酞类化合物
- Author:
Xiang YUAN
;
Bing HAN
;
Zi-ming FENG
;
Jian-shuang JIANG
;
Ya-nan YANG
;
Pei-cheng ZHANG
- Publication Type:Research Article
- Keywords:
italic>Ligusticum chuanxiong;
NMR;
butylphthalides
- From:
Acta Pharmaceutica Sinica
2020;55(11):2674-2678
- CountryChina
- Language:Chinese
-
Abstract:
Three butylphthalide derivatives were isolated from the Rhizome of Ligusticum chuanxiong using a series of isolation and purification approaches including macroporous resin, ODS-A column, Sephadex LH-20 and preparative HPLC. These structures were elucidated based on extensive spectroscopic data (UV, IR, HR-ESI-MS and NMR) and identified as (3Z,3aE)-(6R,7R,2'S)-6-hydroxy-7-(2-carboxyl-2-hydroxyethylthio)-3-(2-hydroxybutylidene)-4,5,6,7-tetrahydro-phthalide (1), (3Z,3aZ)-3-butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-phthalide 7-O-α-D-glucopyranosyl-(1→2)-β-D-fructo-furanoside (2) and 3-(3-β-D-glucopyranosyloxy-butylidene)-7-hydroxy-phthalide (3).
