Research advances on structural modifications to resveratrol and their effect on biological activities
10.16438/j.0513-4870.2020-0745
- VernacularTitle:白藜芦醇的结构修饰与生物活性研究进展
- Author:
Li HAN
;
Hong-peng LI
;
Wen-ling LI
- Publication Type:Research Article
- Keywords:
resveratrol;
structural modification;
resveratrol derivative;
anticancer;
biological activity
- From:
Acta Pharmaceutica Sinica
2020;55(11):2558-2569
- CountryChina
- Language:Chinese
-
Abstract:
Resveratrol possesses a wide range of biological activities, such as anti-cancer, anti-oxidation, induction of apoptosis, etc., but its poor drug properties, rapid metabolism, low target selectivity and bioavailability limit its application value. Studies have shown that modification of the structure of natural compounds can improve their pharmacological activities. To improve the bioavailability of resveratrol, many researchers have undertaken the synthesis and activity evaluation of resveratrol derivatives and analogues. They have modified the phenolic hydroxyl groups, double bonds and benzene ring of resveratrol so as to further understand the interactions among functional groups and its structure-activity relationship. In this paper, we review the chemical structures, synthetic methods and mechanisms of biological activity of resveratrol monomer derivatives as well as their related therapeutic applications, especially in the anticancer area over the last decade. This will provide some reference value for the further research and development of resveratrol-related drugs.
