Metabolism and pharmacokinetics of drugs applied for the treatment of Corona Virus Disease 2019 (COVID-19)
10.16438/j.0513-4870.2020-0696
- VernacularTitle:抗新型冠状病毒肺炎 (COVID-19) 药物的代谢和药动学
- Author:
Lu-lu PAN
;
Da-fang ZHONG
- Publication Type:Research Article
- Keywords:
COVID-19;
metabolism;
pharmacokinetics
- From:
Acta Pharmaceutica Sinica
2020;55(11):2570-2579
- CountryChina
- Language:Chinese
-
Abstract:
Based on Chinese clinical guidance for COVID-19 pneumonia diagnosis and treatment (7th edition), the metabolism and pharmacokinetics of drugs used in clinical treatment of COVID-19 were reviewed. The antiviral drugs include remdesivir, chloroquine/hydroxychloroquine, lopinavir/ritonavir, favipiravir, arbidol, baicalin, baicalein and forsythin. Among them, the metabolism and pharmacokinetics of arbidol, baicalin and forsythin are the research results of the author's laboratory. This article aims to provide reference for the efficacy evaluation and rational drug use of COVID-19.
