Research progress of layer-by-layer self-assembly technology in drug delivery

VernacularTitle:逐层自组装技术在药物递送中的研究进展
Author: Jin-wei DI ; Yi-meng DU ; Xiang GAO ; Hui ZHANG ; Nan LIU ; Ai-ping ZHENG ; Jing GAO
Publication Type:Research Article
Keywords: layer-by-layer self-assembly; rug carrier; stimuli-responsive; biomaterial; rug delivery system
From: Acta Pharmaceutica Sinica 2020;55(11):2595-2605
CountryChina
Language:Chinese
Abstract: In recent years, layer-by-layer self-assembly (LbL) has developed rapidly. It has been widely used in various industries such as medicine and metallurgy because of its simplicity, flexibility and controllability. In the study of drug delivery system, hollow microcapsules constructed by LbL method as drug carrier have great advantages in drug release, circulation in vivo and bioavailability, providing a technical platform for targeted drug release. In this paper, we summarize the types of film-forming materials and the driving force used in LbL technology, the way of loading drug into hollow micro capsule, and the variety of loaded drugs. We focus on the release mechanism, its evaluation and safety evaluation of self-assembled film as drug carrier in vivo and in vitro. The review shows the great application prospect of LbL technology in the field of drug delivery.