Research progress of GWAS in hyperuricemia

VernacularTitle:高尿酸血症GWAS研究进展
Author: Mingzhu XU ^{1
,

2} ; Xin XU ^{1
,

2} ; Yang XIA ^{1
,

2} ; Qijun WU ^{1
,

2} ; Yuhong ZHAO ^{1
,

2}
Author Information

1. Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China
2. Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang Liaoning 110004, China
Publication Type:Journal Article
Keywords: Hyperuricemia; Gene; Genome-wide association study
From: Journal of Public Health and Preventive Medicine 2020;31(5):109-113
CountryChina
Language:Chinese
Abstract: Hyperuricemia is a chronic disease caused by the imbalance of uric acid synthesis and excretion, which is influenced by both environmental and genetic factors. The results of genome-wide association analysis related to hyperuricemia in different regions during the past decade have shown that genes related to hyperuricemia may be region- specific. This article summarizes the genes detected by GWAS, and describes some of the involved molecular mechanisms. The genes related to hyperuricemia shared by people in Europe, Asia, Africa and South America, and genes related to hyperuricemia unique to Asian populations are reviewed in this article. In addition, some of the genes’ functions are discussed to enhance the understanding of the pathogenesis of hyperuricemia.