Excellent Local Tumor Response after Fractionated Stereotactic Radiation Therapy for Locally Recurrent Nasopharynx Cancer.
- Author:
Yong Chan AHN
1
;
Do Hoon LIM
;
Dong Rak CHOI
;
Moon Kyung KIM
;
Dae Yong KIM
;
Seung Jae HUH
;
Chung Hwan BAEK
;
Kwang Chol CHU
;
Sung Soo YOON
;
Keunchil PARK
Author Information
1. Department of Radiation Oncology, Samsung Medical Center, College of Medicine, Sung Kyun Kwan University, Korea.
- Publication Type:Original Article
- Keywords:
Nasopharynx;
Cancer;
Local recurrence;
Fractionated Stereotactic Radiation Therapy;
Reirradiation
- MeSH:
Drug Therapy;
Follow-Up Studies;
Humans;
Nasopharyngeal Neoplasms*;
Nasopharynx*;
Neoplasm Metastasis
- From:Journal of the Korean Society for Therapeutic Radiology
1997;15(1):19-26
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study is to report experience with Fractionated Stereotactic Radiation Therapy (FSRT) for locally recurrent nasopharynx cancer after curative conventional radiation therapy. MATERIALS AND METHODS: Three patients with locally recurrent and symptomatic nasopharynx cancer were given FSRT as reirradiation method between the period of September of 1995 and August of 1996. For two patients, application of FSRT is their third radiation therapy directed to the nasopharynx. Two patients were given low dose chemotherapy as radiation sensitizer concurrently with FSRT. Authors used 3-dimensional coordinate system by individually made, relocatable Gill-Thomas-Cosman (GTC) stereotactic frame and multiple non-coplanar arc therapy dose planning was done using XKnife-3. Total of 45 Gy/18 fractions or 50 Gy/20 fractions were given. RESULTS: Authors observed satisfactory symptomatic improvement and remarkable objective tumor size decrease by follow-up MR images taken 1 month post-FSRT in all three patients, while no neurologic side effect attributable to reirradiation was noticed. Two died at 7 and 9 months with loco-regional and distant seeding outside FSRT field, while one patient is living for 4 month. CONCLUSION: Authors experienced satisfactory therapeutic effectiveness and safety of FSRT as reirradiation method for locally recurrent nasopharynx cancer. Development of more effective systemic chemotherapeutic regimen is desired for distant metastasis.
