Effects of Lidocaine, Fentanyl, and Esmolol on Blood Pressure and Heart Rate Changes owing to Endotracheal Intubation during Propofol Induction.
10.4097/kjae.1996.31.2.195
- Author:
Hee Roung CHOI
1
;
Guie Yong LEE
;
Choon Hi LEE
Author Information
1. Department of Anesthesiology, College of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Complications cardiovascular;
Intubation;
tracheal complications;
Pharmacology lidocaine;
fentanyl;
esmolol
- MeSH:
Anesthesia;
Anesthesia, General;
Blood Pressure*;
Fentanyl*;
Heart Rate*;
Heart*;
Hypertension;
Intubation;
Intubation, Intratracheal*;
Isoflurane;
Laryngoscopy;
Lidocaine*;
Nitrous Oxide;
Oxygen;
Propofol*;
Tachycardia
- From:Korean Journal of Anesthesiology
1996;31(2):195-201
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Laryngoscopy and endotracheal intubation for general anesthesia cause tachycardia and hypertension due to sympathetic stimulation. The purpose of this study is comparison of effects of lidocaine, fentanyl, and esmolol on blood pressure and heart rate changes owing to tracheal intubation during propofol induction. METHODS: Pateints were randomly received one of the following study drug intravenously prior to induction : Group 1(normal saline 5 ml, n=20) ; Group 2 (lidocaine 1.5 mg/kg, n=20) ; Group 3 (fentanyl 2 microgram/kg, n=20) ; Group 4 (esmolol 1.0 mg/kg, n=20). Anesthesia was induced with propofol 2.5 mg/kg IV and then maintained with 50% nitrous oxide in oxygen and 1.0 vol% isoflurane. Systolic and diastolic blood pressure and heart rate were measured preinduction, after induction, immediately after intubation, and 1, 3, 5, 7, 9, 11 minutes following intubation. RESULTS: After intubation, the increase in systolic blood pressure and heart rate were blunted significantly compared with the control group in the group 3 (p<0.05). In the group 4, the increase in blood pressure was not suppressed but modified and tachycardia was not prevented after intubation. CONCLUSIONS: Fentanyl 2 microgram/kg was suppressed blood pressure changes and effective in attenuating tachycardia during propofol induction compare with control and lidocaine groups. Esmolol 1.0mg/kg was effective in attenuating blood pressure changes owing to tracheal intubation.
