Clinical Characteristics of Human Parvovirus B19 Infection in Children
- Author:
Kyo Jin JO
1
;
Yeoun Joo LEE
;
Kyung Mi PARK
;
Eu Jeen YANG
;
Sukdong YOO
;
Taek Jin LIM
;
Su Eun PARK
Author Information
- Publication Type:Original Article
- From:Pediatric Infection & Vaccine 2020;27(2):111-116
- CountryRepublic of Korea
-
Abstract:
Purpose:Human parvovirus B19 infection is widespread and has a heterogeneous clinical spectrum, ranging from asymptomatic infection to potentially life-threatening complications. We investigated the various clinical features of human parvovirus B19 infection during an outbreak of the virus in our community.
Methods:A retrospective chart review study was conducted at the Pusan National University Children's Hospital from December 2017 to April 2019. We investigated the clinical features of children with parvovirus B19 immunoglobulin M or parvovirus B19 DNA detected using polymerase chain reaction.
Results:A total of 24 children were diagnosed with parvovirus B19 infection. Twelve (50%) had lace form rashes, and four (16.7%) had petechial rashes. Two (8.3%) were diagnosed with fever without a focus. Six (25%) developed aplastic crisis as a complication of infection, of whom three were previously diagnosed with hereditary spherocytosis and three with acute lymphoblastic leukemia.
Conclusions:In addition to erythema infectiosum, the parvovirus B19 infection can present clinically with various types of rashes and fever without a focus. Furthermore, hematologic manifestations such as neutropenia and aplastic crisis can occur during infection.
