Epigenetic Approaches to the Treatment of Renal Cell Cancer
10.22465/kjuo.2020.18.2.78
- Author:
Seong Hwi HONG
1
;
Jiyoung LEE
;
Eun Bi JANG
;
Sung Yul PARK
;
Hong-Sang MOON
;
Young Eun YOON
Author Information
1. Department of Urology, Hanyang University College of Medicine, Seoul, Korea
- Publication Type:Review Article
- From:Korean Journal of Urological Oncology
2020;18(2):78-90
- CountryRepublic of Korea
- Language:English
-
Abstract:
To summarize the epigenetics in renal cell carcinoma (RCC) and discuss the potential use of epigenetic modifiersas RCC biomarkers and treatments. Pertinent articles available on PubMed and google scholar database pertainingto kidney cancer and epigenetics were reviewed. Metastatic RCC is one of the most difficult cancers to treat.Although RCC is commonly known to be caused by VHL mutations, it is not enough to understand the completepathophysiology of RCC. Epigenetic factors can play a fundamental role in the pathogenesis of RCC. Epigeneticregulators are classified as epigenetic writers, readers, and erasers according to their role. In this review, wediscuss the potential role of epigenetic regulators as a biomarker for RCC. We also review medications thattarget epigenetic enzymes and are currently tried in RCC therapy.
