Next-Generation Sequencing in Prostate Cancer
10.22465/kjuo.2020.18.1.18
- Author:
Seong Hyeon YU
1
;
Taek Won KANG
Author Information
1. Department of Urology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea
- Publication Type:Review Article
- From:Korean Journal of Urological Oncology
2020;18(1):18-23
- CountryRepublic of Korea
-
Abstract:
Prostate cancer is one of the most common cancer worldwide, androgen-deprivation therapy (ADT) has been the mainstream of treatment after treatment failure of localized cancer. However, despite the rapid initial response of ADT, most patients eventually progress to metastatic castration-resistant prostate cancer (mCRPC). Treatment decisions for patients with mCRPC are a very complex process, and its response is varied and difficult to predict due to individual differences. Therefore, novel biomarkers and therapeutic targets based on better understanding of molecular landscape of prostate cancer are needed. In this review, we summarized the genomic information, informative biomarkers and potential molecular targets using next-generation sequencing technology of prostate cancer. (Korean J Urol Oncol 2020;18:18-23)
