A Retrospective Study on the Effect of 1-Year Clozapine Administration on Platelet Activity in Patients with Schizophrenia or Schizoaffective Disorder
10.22722/KJPM.2020.28.1.36
- Author:
EunJa JANG
1
;
Jong Wook LEE
;
Seung-Jun KIM
;
Hong-Seok OH
;
Woo Young IM
;
Na-Hyun LEE
;
Ji-Woong KIM
Author Information
1. Department of Psychiatry, College of Medicine, Konyang University, Daejeon, Korea
- Publication Type:Original Article
- From:Korean Journal of Psychosomatic Medicine
2020;28(1):36-41
- CountryRepublic of Korea
-
Abstract:
Objectives:：Clozapine has been known to increase the possibility of developing cardio/cerebrovascular diseases, and the platelet activation has been deemed to be related to the occurrence of them. In author’s previous study, we observed the increase of platelet activity with short-term clozapine administration. This study was conducted, as a follow-up study, to investigate the effect of clozapine on the platelet activity when administered continuously for long-term period of time of 1 year.
Methods:：The medical records of the patients with schizophrenia or schizoaffective disorder who were treated with clozapine for 1 year were retrospectively reviewed. The degree of platelet activation was assessed by measuring the mean platelet component.
Results:：Total of 24 patients were enrolled. 9 of them (37.5%) were male and 15 of them (62.5%) were female. In the Wilcoxon sign-ranks test, no significant change was observed between the mean platelet factor values at the beginning and at the end of one year.
Conclusions:：No significant changes of mean platelet activity were observed after continued administration of clozapine for 1 year. Considering the author’s previous findings that observed a prominent decrease of mean platelet component after short-term clozapine administration, the result of this study suggests the possibility that the activity of the platelet may change depending on the duration of the clozapine administration.
