Analysis of HIV RNA Genotypes and Quantitative Values of HIV NAT Reactive Blood Donations
10.17945/kjbt.2020.31.2.141
- Author:
Jung-won KANG
1
;
Jae-won KANG
;
Dae Ho KO
;
Miae YOUN
;
So-Yong KWON
Author Information
1. Korean Redcross Blood Transfusion Research Institute, Korean Red Cross, Wonju, Korea
- Publication Type:Original Article
- From:Korean Journal of Blood Transfusion
2020;31(2):141-150
- CountryRepublic of Korea
-
Abstract:
Background:The Korean Red Cross adopted HIV NAT for blood donor screening in 2005 using a minipool assay. In June 2012, the NAT system was replaced with the individual assay. This study examined the characteristics of HIV NAT reactive blood donors to determine if there was any difference in their features between 10 years ago and later.
Methods:This study analyzed the HIV RNA quantitative values and the distribution of HIV subtypes using 118 HIV NAT positive blood donations (37 in 2007, 20 in 2008, 32 in 2017 and 29 in 2018).
Results:No significant variations of the quantitative values of HIV RNA and the distribution of HIV subtypes 10 years ago and later were observed. This study failed to produce quantitative values of three samples due to the low titer. The mean titer of HIV RNA of the remaining 115 samples were 5.14×10 4 IU/mL. The dominant HIV subtype of the HIV NAT reactive donors was B showing 54.2% (64/118). Approximately 5.9% (7/118) of the samples showed the HIV subtype C. Forty-seven samples (39.8%) showed the circulating recombinant form (CRF).
Conclusion:The rate of HIV subtype B in this study (54.2%) has decreased compared to the results of the past study (95.2%). Some of the cases showing CRF were identified as B in the past study because CRF3, 8, 9, 14, and 15 are recombinant forms, including subtype B.
