Elastin Degradation and Collagen III Deficiency in the Superficial Temporal Arteries of Patients with Intracranial Aneurysms.
- Author:
Chul Yoon HWANG
1
;
Mi Suk ROH
;
Jae Taeck HUH
Author Information
1. Department of Neurosurgery, Dong-A University College of Medicine, Busan, Korea. jthuh@donga.ac.kr
- Publication Type:Original Article
- Keywords:
Elastin;
Collagen III;
Superficial temporal artery;
Intracranial aneuryam
- MeSH:
Aneurysm;
Animals;
Collagen Type III;
Collagen*;
Craniotomy;
Elastin*;
Eosine Yellowish-(YS);
Female;
Hematoxylin;
Humans;
Hypertension;
Intracranial Aneurysm*;
Mice;
Middle Aged;
Risk Factors;
Temporal Arteries*
- From:Journal of Korean Neurosurgical Society
2007;42(1):20-26
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We present the difference of histopathologic changes of the internal elastic lamina (IEL) and collagen III in the superficial temporal artery (STA) between aneurysmal patients and non-aneurysmal patients. Also, the pathologic data with clinical features by comparative methods to validate the risk factor of the intracranial aneurysm are presented. METHODS: Samples of the STA were harvested form 38 patients including aneurysmal and non-aneurysmal patients undergoing craniotomy. Paraffin-embedded sections were examined, using hematoxylin and eosin, van Giebson and mouse anti-collagen III staining techniques. Histopathological observations were analysed and correlated with clinical features such as presence of aneurysm, hypertension, age, and sex. RESULTS: Twenty-seven patients had the intracranial aneurysm. Of these 24 patients were 50 years old or older. Nineteen patients had a history of hypertension. Twenty patients were female. Histopathological study demostrated the derangement of IEL and the deficiency of type III collagen were prominent in aneurysmal patients (p<0.05). Fifty years old or older patients did not show correlation with the deficiency of type III collagen, but with the derangement of IEL (p<0.05). The female sex was not correlated with the derangement of IEL but with the deficiency of type III collagen (p<0.05). However, Hypertension was not correlated with these pathologic data. CONCLUSION: Patients with intracranial aneurysms have severe histopathologic changes of the arterial wall showing the derangement of IEL and the deficiency of type III collagen. In the clinico-pathologic study, the advanced age and female sex were considered as risk factors of the intracranial aneurysm.
