The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis
10.12997/jla.2020.9.3.419
- Author:
Han-Teo LEE
1
;
Sanghyeon OH
;
Du Hyun RO
;
Hyerin YOO
;
Yoo-Wook KWON
Author Information
1. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science, Seoul National University, Seoul, Korea
- Publication Type:Review
- From:Journal of Lipid and Atherosclerosis
2020;9(3):419-434
- CountryRepublic of Korea
- Language:0
-
Abstract:
Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic changes relevant for atherosclerosis. Recent studies have shown that the DNA methylation and histone modification systems are closely interrelated and mechanically dependent on each other.Herein, we explore the functional linkage between these systems, with a particular emphasis on several recent findings suggesting that histone acetylation can help in targeting DNA methylation and that DNA methylation may control gene expression during atherosclerosis.
