Immunohistochemical Expression of bcl-2 and PCNA in Acquired Melanocytic Nevi.
- Author:
Tae Jin KIM
1
;
Sung Yul LEE
;
Jong Suk LEE
;
Kyu Uang WHANG
Author Information
1. Department of Dermatology, College of Medicine, Soonchunhyang University Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Acquired melanocytic nevi;
bcl-2;
PCNA
- MeSH:
Cytoplasm;
Dermis;
Homeostasis;
Melanocytes;
Nevus;
Nevus, Intradermal;
Nevus, Pigmented*;
Proliferating Cell Nuclear Antigen*
- From:Korean Journal of Dermatology
2002;40(11):1325-1330
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The histogenesis of acquired melanocytic nevi is still a matter of debate. One considers that nevus cells originate from epidermal melanocytes and the other postulates that nevus cells are of both neural and melanocytic origin. OBJECTIVE: To clarify this controversy, investigation of the growth dynamics and tissue homeostasis of nevi is needed. METHODS: We compared expressions for PCNA and bcl-2 in 12 intradermal nevi and 8 compound nevi by immunohistochemical staining. RESULTS: The results are summarizid as follows: 1. bcl-2 : Both intradermal and compound nevi exhibited strong perinuclear and cytoplasmic staining. There was diminution of staining with progressive descent into the dermis. 2. PCNA : The mean rate of PCNA-positive nevus cells was higher in compound nevi than in intradermal nevi. CONCLUSION: The findings of our study shows considerable differences between intradermal nevi and compound nevi in expressions for PCNA and bcl-2.