Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
10.15430/JCP.2020.25.3.136
- Author:
Rohini GOMATHINAYAGAM
1
;
Ji Hee HA
;
Muralidharan JAYARAMAN
;
Yong Sang SONG
;
Ciro ISIDORO
;
Danny N. DHANASEKARAN
Author Information
1. Stephenson Cancer Center, Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
- Publication Type:Review
- From:Journal of Cancer Prevention
2020;25(3):136-151
- CountryRepublic of Korea
- Language:0
-
Abstract:
Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.
