Implications of specific gene expression patterns in enamel knot in tooth development
10.11620/IJOB.2020.45.1.25
- Author:
Tae-Young KIM
1
;
Sanjiv NEUPANE
;
Yam Prasad ARYAL
;
Eui-Seon LEE
;
Ji-Youn KIM
;
Jo-Young SUH
;
Youngkyun LEE
;
Wern-Joo SOHN
;
Seo-Young AN
;
Jung-Hong HA
;
Chang-Hyeon AN
;
Jae-Young KIM
Author Information
1. Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University, Daegu 41940, Republic of Korea
- Publication Type:Original Article
- From:International Journal of Oral Biology
2020;45(1):25-31
- CountryRepublic of Korea
- Language:0
-
Abstract:
Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
